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Expertise of the month

May 13, 2024

Expertise of the month: Synthetic shortcuts to...

Events

Mar 28, 2024

SpiroChem @ 4 major events in April

Literature

Mar 16, 2024

SpiroChem’s Macrocycle Library delivers clinical candidates

Events

Mar 01, 2024

SpiroChem @ 4 major European events in...

Conferences

Feb 02, 2024

DMCCB Basel Symposium 2024 «Therapeutics by Computational...

Expertise of the month

Jan 30, 2024

Expertise of the month: Identification of a...

Press Releases

Jan 25, 2024

EUROAPI enhances its CDMO capabilities through a...

Conferences

Jan 18, 2024

SpiroChem @ the 4th Alpine Winter Conference...

Reach the Summit

Oct 27, 2023

Climb to the summit with SpiroChem

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Discovery
Process R&D
Fully Integrated Services
Technology
Resources
Careers
About

Get in touch

contact@spirochem.com +41 61 685 9500 Follow us

Informations

Terms & Conditions

Impressum

https://tools.google.com/dlpage/gaoptout
https://allaboutcookies.org/

Stay Connected

Stay inspired with our newsletter subscription, keeping you informed on new concepts, products, solutions & more.

Medicinal Chemistry

Our Mission: Accelerate your project!

Typically : 1-6 chemists

Duration : 3-12+ months

Excellence in chemistry
Creative drug design
Solution and productivity driven
Uncompromised quality

Full MedChem programs or Support for a specific phase:

Hit Validation
Hit/Fragment Expansion
Hit-to-Lead

Lead Optimization
SAR Elucidation
Bioisosteric replacement strategies

Properties Optimization
Back-up programs
IP Evaluation
Patent Filing

Hit Validation
Hit/Fragment Expansion
Hit-to-Lead
Lead Optimization
SAR Elucidation

Bioisosteric replacement strategies
Properties Optimization
Back-up programs
IP Evaluation
Patent Filing

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MedChem Enabling Platforms

Our Mission: Explore new chemical space for you

Typically : 2-5 chemists

Duration : 3-12+ months

Opening of new exit vectors
Late-stage functionalization
Synthesis tractability
Unleashed design

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Fragment Libraries

Our Mission: Address unexplored chemical space and diversity

+700 molecules in stock
Unique design
High sp³ content
Conformationally restricted structures
Scale-up and straightforward analoging guaranteed

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DEL Scaffolds

Our Mission : Offer exclusive scaffolds

Bi- and tri-functionalized scaffolds
Uncharted chemical space
Unique dihedral angles covered
Orthogonal protecting groups
Vectors : COOH, CHO, Aryl halides, Nboc, Nfmoc, boronates

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Route Scouting

Our Mission: Design and implement de novo synthetic routes

Typically: 1-3 chemists

Duration: 3-6+ months

De novo design of synthetic routes to target molecules
Trouble-shooting
Development of efficient in-process controls
Stress test, robustness check
Technology transfer package

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SpiroKits

The must-have medicinal chemistry toolbox designed to:

Provide medchem turnkey solutions
Accelerate projects
Foster chemical space exploration
Support novelty

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Catalog

Our mission: Accelerate your R&D

+13 000 molecules
Innovative building blocks
Purity > 95%
Milligram to hundred gram scale
Short delivery time

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Consulting

Our mission: Share our knowledge

Literature analysis
Analysis of SAR results and proposals
Strategy proposals for ADME optimization
Retrosynthetic analysis
Route scouting proposals
Patent gap analysis
Support for patent filing

*hourly rate, daily rate or project-based fee

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Computational Chemistry

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