Publications

Urolithin derivatives and therapeutic uses

Reviews and Patents

Year: 2024 | Authors: P. C. Sennhenn, S.Oumouch, P. Andreux | Reference: WO2024023585A2

Diversification of Simple Arenes into Complex (Amino)cyclitols

IP-Space

Year: 2024 | Authors: E. Angelini, M. Martinelli, E. Roà, C. N. Ungarean, C. Salomé, Q. Lefebvre, C. Bournez, T. C. Fessard, D. Sarlah | Reference: Chem. Eur. J. 2024, 30, 6, e202303262

Synthesis of Borylated Carbocycles by [2 + 2]-Cycloadditions and Photo-Ene Reactions

IP-Space

Year: 2024 | Authors: Jarett M. Posz, Neetu Sharma, Paige A. Royalty, Yanyao Liu, Christophe Salome, Thomas C. Fessard, M. Kevin Brown | Reference: J. Am. Chem. Soc. 2024

Process

Reviews and Patents

Year: 2023 | Authors: M. Johnson, M. Wallace, R. Lagoutte, R. Beaud | Reference: WO2023067518A1

2,5-disubstituted bicyclo[2.1.1]hexanes as rigidified cyclopentane variants

IP-Space

Year: 2023 | Authors: S. Paul, D. Adelfinsky, C. Salomé, T. C. Fessard, M. K. Brown | Reference: Chem. Sci. 2023, 14, 8070-8075

Preparation of 3,5-Methanobenzo[b]azepines: An sp3-Rich Quinolone Isostere

IP-Space

Year: 2023 | Authors: L. Herter, T. Perrin, T. C. Fessard, C.Salomé | Reference: Org. Lett. 2023, 25, 33, 6161–6166

Silver(I)-Catalyzed Synthesis of Cuneanes from Cubanes and their Investigation as Isosteres

IP-Space

Year: 2023 | Authors: E. Smith, C. Salomé, Q. Lefebvre, A. Valery, M. Böcü, H. W. Lam | Reference: J. Am. Chem. Soc. 2023, 145, 30, 16365–16373

Dewar Pyridines: Conformationally Programmable Piperidine Isosteres

IP-Space

Year: 2023 | Authors: J. Petrovcic, C. Salomé, Q. Lefebvre, T. C. Fessard, D. Sarlah | Reference: ChemRxiv. 2023; doi:10.26434/chemrxiv-2023-jgr4j

Synthesis of 2-Azanorbornanes via Strain-Release Formal Cycloadditions Initiated by Energy Transfer

IP-Space

Year: 2023 | Authors: Y.-C. Chang, C. Salomé, T. Fessard, M. K. Brown | Reference: Angew. Chem. Int. Ed. 2023, 62, 51, e202314700

Nickel-Photoredox-Catalyzed Synthesis of sp2−sp3 Fragments and the Impact of Bicycloalkane Isosteric Replacement on Their Physical-Chemical Properties

Fragments

Year: 2023 | Authors: Q. Lefebvre, M. Böcü, C. Giorgiutti, T. C. Fessard | Reference: Helv. Chim. Acta. 2023, 106, 4, e202200189

Introducing covalent warheads on spirocyclic sp2–sp3 fragments by innate C–H functionalization

Fragments

Year: 2023 | Authors: M. Martinelli, C. Giorgiutti, T. C. Fessard, Q. Lefebvre | Reference: Org. Biomol. Chem. 2023, 21, 9230-9235

Reactivity and Selectivity of Azaspirocycles in Radical C–H Functionalization

Fragments

Year: 2023 | Authors: C. N. Ungarean, Q. Lefebvre, T. C. Fessard, B. Morandi | Reference: Org. Lett. 2023

Transformer Performance for Chemical Reactions: Analysis of Different Predictive and Evaluation Scenarios

Computational Chemistry

Year: 2023 | Authors: F. Jaume-Santero, A. Valery, C. Bournez, T. C. Fessard, D. Teodoro | Reference: J. Chem. Inf. Model. 2023, 63, 7, 1914–1924

2.03 - Other Fused Azetidines, Azetines and Azetes

Book Chapter

Year: 2022 | Authors: R. Lagoutte, Q. Lefebvre, C. Salome, T. Fessard | Reference: Comprehensive Heterocyclic Chemistry IV, 2, 2022,159-211

Preparation of new bicyclo[2.1.1]hexane compact modules: an opening towards novel sp3-rich chemical space

IP-Space

Year: 2022 | Authors: L. Herter, I. Koutsopetras, L. Turelli, T. C. Fessard, C. Salomé | Reference: Org. Biomol. Chem. 2022, 20, 9108-9111

Strain-Release [2π + 2σ] Cycloadditions for the Synthesis of Bicyclo[2.1.1]hexanes Initiated by Energy Transfer

IP-Space

Year: 2022 | Authors: R. Guo, L. Herter, C. Salomé, S. E. Braley, T. C. Fessard, M. K. Brown | Reference: J. Am. Chem. Soc. 2022, 144, 18, 7988–7994

[2]-Ladderanes as isosteres for meta-substituted aromatic rings and rigidified cyclohexanes

IP-Space

Year: 2022 | Authors: R. C. Epplin, L. Herter, C. Salomé, T. C. Fessard, M. K. Brown | Reference: Nat. Commun. 2022, 13, 6056

3-(Nitromethylene)oxetane: a very versatile and promising building block for energetic oxetane based monomers

Energetic materials

Year: 2022 | Authors: M. Born, T. C. Fessard, L. Göttemann, T. M. Klapötke | Reference: Mater. Adv. 2022, 3, 3479-3489

Energetic but insensitive spiro-tetrahydrotetrazines based on oxetane-3-one

Energetic materials

Year: 2022 | Authors: T. C. Fessard, I. Gospodinov, T. M. Klapötke | Reference: J. Heterocycl. Chem. 2022, 59, 10, 1781-1789

Synthesis of 1,4-diazaspiro[5.5]undecan-3-one

Reviews and Patents

Year: 2021 | Authors: S. E. Schneider, H. White, T. C. Fessard, S.Beldar | Reference: US20210179567A1

3,3-Dinitratooxetane – an important leap towards energetic oxygen-rich monomers and polymers

Energetic materials

Year: 2021 | Authors: M. Born, T. C. Fessard, L. Göttemann, T. M. Klapötke | Reference: Chem. Commun. 2021, 57, 2804-2807

A GAP Replacement: Improved Synthesis of 3-Azidooxetane and Its Homopolymer Based on Sulfonic Acid Esters of Oxetan-3-ol

Energetic materials

Year: 2021 | Authors: M. Born, T. C. Fessard, L. Göttemann, J. Plank, T. M. Klapötke | Reference: J. Org. Chem. 2021, 86, 18, 12607–12614

Pushing the Frontiers of Accessible Chemical Space to Unleash Design Creativity and Accelerate Drug Discovery

Reviews and Patents

Year: 2020 | Authors: T. C. Fessard, K. Goncharenko, Q. Lefebvre, C. Salomé | Reference: Chimia 2020, 74, 803

Process for preparing 3'-o-amino-ribonucleotide

Reviews and Patents

Year: 2020 | Authors: I. Sarac, C. Barboux, S. Niyomchon, F. Beaufils, M. Bueschleb | Reference: WO2020165334A1

Accelerating fragment-based library generation by coupling high-performance photoreactors with benchtop analysis

Fragments

Year: 2020 | Authors: Q. Lefebvre, C. Salomé, T. C. Fessard | Reference: Beilstein J. Org. Chem. 2020, 16, 982–988

Activating Pyrimidines by Pre-distortion for the General Synthesis of 7-Aza-indazoles from 2-Hydrazonylpyrimidines via Intramolecular Diels–Alder Reactions

Methodology

Year: 2019 | Authors: V. Le Fouler, C. Salomé, T. Fessard, F. Liu, K. N. Houk, N. Blanchard | Reference: J. Am. Chem. Soc. 2019, 141, 40, 15901–15909

Domino Pd0-Catalyzed C(sp3)–H Arylation/Electrocyclic Reactions via Benzazetidine Intermediates

Methodology

Year: 2018 | Authors: R. Rocaboy, D. Dailler, C. Salomé, E. Clot, O. Baudoin | Reference: Angew. Chem. Int. Ed. 2018, 57, 37, 12131-12135

On water N-arylation of oxetanylamines for the preparation of N-aryl-oxetanylamines; potentially useful aryl-amide isosteres

Methodology

Year: 2018 | Authors: M. Bollenbach, T. Fessard, M. Schmitt, C. Salomé | Reference: " Chem. Commun. 2019, 55, 1623-1626"

Categories:

Urolithin derivatives and therapeutic uses

Diversification of Simple Arenes into Complex (Amino)cyclitols

Synthesis of Borylated Carbocycles by [2 + 2]-Cycloadditions and Photo-Ene Reactions

Process

2,5-disubstituted bicyclo[2.1.1]hexanes as rigidified cyclopentane variants

Preparation of 3,5-Methanobenzo[b]azepines: An sp3-Rich Quinolone Isostere

Silver(I)-Catalyzed Synthesis of Cuneanes from Cubanes and their Investigation as Isosteres

Dewar Pyridines: Conformationally Programmable Piperidine Isosteres

Synthesis of 2-Azanorbornanes via Strain-Release Formal Cycloadditions Initiated by Energy Transfer

Nickel-Photoredox-Catalyzed Synthesis of sp2−sp3 Fragments and the Impact of Bicycloalkane Isosteric Replacement on Their Physical-Chemical Properties

Introducing covalent warheads on spirocyclic sp2–sp3 fragments by innate C–H functionalization

Reactivity and Selectivity of Azaspirocycles in Radical C–H Functionalization

Transformer Performance for Chemical Reactions: Analysis of Different Predictive and Evaluation Scenarios

2.03 - Other Fused Azetidines, Azetines and Azetes

Preparation of new bicyclo[2.1.1]hexane compact modules: an opening towards novel sp3-rich chemical space

Strain-Release [2π + 2σ] Cycloadditions for the Synthesis of Bicyclo[2.1.1]hexanes Initiated by Energy Transfer

[2]-Ladderanes as isosteres for meta-substituted aromatic rings and rigidified cyclohexanes

3-(Nitromethylene)oxetane: a very versatile and promising building block for energetic oxetane based monomers

Energetic but insensitive spiro-tetrahydrotetrazines based on oxetane-3-one

Synthesis of 1,4-diazaspiro[5.5]undecan-3-one

3,3-Dinitratooxetane – an important leap towards energetic oxygen-rich monomers and polymers

A GAP Replacement: Improved Synthesis of 3-Azidooxetane and Its Homopolymer Based on Sulfonic Acid Esters of Oxetan-3-ol

Pushing the Frontiers of Accessible Chemical Space to Unleash Design Creativity and Accelerate Drug Discovery

Process for preparing 3'-o-amino-ribonucleotide

Accelerating fragment-based library generation by coupling high-performance photoreactors with benchtop analysis

Activating Pyrimidines by Pre-distortion for the General Synthesis of 7-Aza-indazoles from 2-Hydrazonylpyrimidines via Intramolecular Diels–Alder Reactions

Domino Pd0-Catalyzed C(sp3)–H Arylation/Electrocyclic Reactions via Benzazetidine Intermediates

On water N-arylation of oxetanylamines for the preparation of N-aryl-oxetanylamines; potentially useful aryl-amide isosteres

Method of preparing substituted bicyclo[1 1 1]pentanes

Improving Nonspecific Binding and Solubility: Bicycloalkyl Groups and Cubanes as para-Phenyl Bioisosteres

Four-Membered Ring-Containing Spirocycles: Synthetic Strategies and Opportunities