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Analytical electrochemistry has been used for decades to characterize the redox behavior of chemicals. However, in recent years, there has been a notable surge in preparative electrochemical chemistry, thanks to advancements in chemical synthesis and chemical engineering. Electrochemical synthesis presents significant advantages over traditional chemistry, offering precise stoichiometric and temporal control over reactions while circumventing the use of hazardous oxidants and reductants.
1.Analytical electrochemistry - techniques such as cyclic voltammetry, chronoamperometry, and differential pulse voltammetry provide detailed molecular information on the redox behavior, stability, and reactivity of compounds.
2.Preparative electrochemistry - leveraging electrical energy to drive synthetic reactions, facilitating oxidation and reduction reactions, C–C and C–N bond formation, and green and sustainable processes.
Preparative organic electrosynthesis is well suited to atom-efficient small-scale reactions, as well as large-scale, bulk chemical synthesis. This technology is powerful for medicinal chemistry projects, accelerating and strengthening structure-activity relationships (SAR), and supporting fragment-based drug design through fragment expansion.
At SpiroChem, we have validated several modern electrochemical transformations to serve our needs in library synthesis and fragment coupling. These include accessing previously elusive chemical space, enabling regioselective C-H functionalization of sp3 compounds, and improving the efficiency of our processes.
