Macrocycle Library
Collection of 8000+ macrocycles
Our SpiroQUEST™ Library has been carefully designed to include many chemotypes while providing a usefully diverse range of parameters. SpiroChem also offers library design services complementing its current macrocycle compound collection and leveraging its macrocycle expertise for your needs.
Enrich your screening decks with enabled beyond the ‘Rule of Five’ starting points
Macrocycles are privileged structures in medicinal chemistry as they successfully expand the available compound space and have special features that make them druggable despite being beyond the ‘Rule of Five’.
About Macrocycles
Macrocycles are privileged structures in medicinal chemistry as they:
- Provide diverse functionality and stereochemical complexity in a conformationally pre-organized ring structure
- Are semi-rigid compounds, a compromise between structural pre-organization (entropy) and sufficient flexibility to mold to a target surface and maximize binding (induced fit)
- Can demonstrate drug-like physicochemical and good pharmacokinetic properties such as solubility, lipophilicity, metabolic stability, cell (and blood-brain barrier) permeability and bioavailability beyond the ‘Rule of Five’