Spirochem

Macrocycle library

Advancing your research program by delivering the world’s best chemistry. Collection of 8000+ macrocycles. Discover more!
  • Provide diverse functionality and stereochemical complexity in a conformationally pre-organized ring structure
  • Are semi-rigid compounds, a compromise between structural pre-organization (entropy) and sufficient flexibility to mold to a target surface and maximize binding (induced fit)
  • Can demonstrate drug-like physicochemical and good pharmacokinetic properties such as solubility, lipophilicity, metabolic stability, cell (and blood-brain barrier) permeability and bioavailability beyond the ‘Rule of Five’
Advancing your research program by delivering the world’s best chemistry. Collection of 8000+ macrocycles. Discover more!
Advancing your research program by delivering the world’s best chemistry. Collection of 8000+ macrocycles. Discover more! Advancing your research program by delivering the world’s best chemistry. Collection of 8000+ macrocycles. Discover more!
  • Step 1: Purchase of SpiroQUEST™ Library
  • Format
    • Available as 10 mM DMSO solution
    • Standard volumes: 2 or 5 µL
    • Plate format: Greiner 784201
    • Other plate format available on request
  • Step 2: Screening of the SpiroQUEST™ Library
  • Screening
    • Performed by partner, or third-party screening center
    • Note: SpiroChem has screening partners and can arrange/coordinate screening efforts.
  • Step 3: Hit Analysis and Validation
  • Workflow
    • Hit analysis by SpiroChem
    • Preparation of a validation library of 48-96 analogues around selected hits
    • Unblinding* of hits
    • Resynthesis of hits and supply
  • Step 4: Hit-to-Lead and Lead Optimization
  • Workflow
    • Hit-to-lead and lead optimization
  • Contact us to discuss your research
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