Bioisosteric Replacement Strategies

A leading chemistry contract research organization in bioisosteric switch strategies

Bioisosteric replacement strategies

Bioisosteric replacement is a key component of compound optimization.

Bioisosteric replacement is a useful tool for altering the pharmacokinetics or toxicity of a lead compound, by generating new molecules with similar biological properties to the parent compound, but different physical-chemical properties and favorable ADME properties. These strategies can be physicochemically or topologically based. SpiroChem has established itself as a world-leading expert on bioisosteric switch strategies.

A leading chemistry contract research organization in bioisosteric switch strategies. Learn more!

Pushing the limits on novel concepts for bioisosteric switch strategies. SpiroChem can offer bioisosteric replacements with enhanced metabolic stability.

We are constantly proposing new hypotheses and developing new concepts to help medicinal chemists improve their lead candidates—expanding into new IP-free chemical spaces.

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SpiroChem is unparalleled in its offering with a world-class team of chemistry experts providing high-quality solutions. We are a dependable partner with a wealth of experience.

Testimonials

“SpiroChem has been our very effective partner in drug development. They showed outstanding performance even with demanding syntheses of compounds and they delivered what they promised on time. Their professionalism was obvious in every step, from targeted synthesis design to implementation and report. The SpiroChem team combines creativity and commitment, as well as efficient problem-solving capability, that are keys to the success of the project. Smooth communication facilitated our productive collaboration. I would highly recommend SpiroChem.”