Lead Optimization

Maximizing success by advancing lead compounds to clinical-grade through expert lead optimisation.

Lead optimization aims to convert promising lead compounds into drugs suitable for human clinical evaluation.

Lead optimization is the fine tuning of multiple molecule parameters, which ensures novelty, safety and potency, and requires expertise in optimizing absorption, distribution, metabolism, excretion, and toxicity properties.

With a comprehensive understanding of drug discovery and process R&D programs, our expert lead optimization team helps advance and accelerate your successful leads to drug candidates. We also offer a complete range of computational chemistry services dedicated to lead optimization.

Our expert lead optimization team helps advance and accelerate your successful leads to drug candidates. Learn more!

We offer integrated discovery services within our high-quality trusted research partner network, guiding you through lead optimization, as part of our full coverage of modern pharmaceutical drug discovery.

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What our clients
say about us

SpiroChem is unparalleled in its offering with a world-class team of chemistry experts providing high-quality solutions. We are a reliable partner with a wealth of experience.

Testimonials

“SpiroChem is a reliable partner for our lead optimization programs. We have been working with SpiroChem for several years in a fruitful and trustworthy relationship. The SpiroChem team - based on strong knowledge of synthetic and medicinal chemistry – always performs effectively to boost our structure-activity relationship studies. And when it comes to the synthesis of challenging targets, SpiroChem also solved many synthetic issues with unique and sophisticated ideas that no other CRO can provide. It stimulates us and brings great results and value to our projects. For this reason, SpiroChem is a highly recommended partner for discovery.”