Our High-Diversity Fragment Library comprises hundreds of in stock compounds with MW ≤ 300, ClogP ≤ 3.0 and TPSA≤ 60, originating from the exploratory work of SpiroChem on the synthesis of sp3-rich (more 3D-like) scaffolds, conformationally-restricted and strained building blocks. To optimize drug-like properties, covalent modifiers and toxicophores have been excluded, and a large set of fluorinated fragments has been included. Noteworthy, our Fragment Library compiles exclusive sp2/sp3 hybrid scaffolds integrating both spirocyclic or bicycloalkyl moieties connected/fused to a heteroaromatic groups. Such unique motif will allow to address unexplored chemical space and tackle undruggable biological targets.
Synthetic tractability is as important as diversity! What would be the use of a complex fragment that you cannot easily modify or evolve later on? Our motto is “Make the molecules you SHOULD, not just the one you COULD”. At SpiroChem, we do not only provide milligrams of each Fragment! Because we master the synthesis of our complex Fragments, we offer synthetic tractability of all the chemical series that we propose. We can provide you with fast-analoging solutions, additional quantities of each Fragment Hit and support in securing new Intellectual Property domains. We will assist you during the Fragment Evolution phase. And if things go well, we can be your outsourcing partner to explore the chemistry further and help you bring your products to lead series and beyond.
In addition, we can synthesize sub-series and propose bioisosteric replacement to expand your research towards new IP.