Our fragments are characterized with MW ≤ 300, ClogP ≤ 3.0 and TPSA≤ 60, originating from the exploratory work of SpiroChem on the synthesis of sp3-rich (more 3D-like) scaffolds, conformationally-restricted and strained building blocks. Our Fragment Library compiles exclusive sp2/sp3 hybrid scaffolds integrating both spirocyclic or bicycloalkyl moieties connected/fused to a heteroaromatic groups. Such unique motif will allow to address unexplored chemical space and tackle undruggable biological targets.
The last decade or so has witnessed a change of paradigm by Life Science companies, who have redirected their screening efforts for hit finding/identification from high throughput screening (HTS) to more modern and flexible techniques such as Fragment-Based Library Screening (FBLS) and DNA-encoded library Technology (DELT). Compared to expensive and often unfruitful HTS campaigns, Fragment-Based Library Screening offers much more flexibility and diversity in the hits identified, due to the small nature of fragments compared to more complex/evolved traditional screening compounds.
Technical advances in biophysical techniques, such as NMR spectroscopy, Surface Plasmon Resonance (SPR), MicroScale Thermophoresis (MST) and other, allow for the use of low molecular weight molecules (Fragments) with low affinity to be identified. Among the criteria governing the development of Fragment Based Drug Discovery, three considerations (MW ≤300, H-bond donors ≤3, H-bond acceptors ≤3, cLogP ≤3), along with rotatable bond count and calculated TPSA limits, are commonly accepted. Finally, it has been established that the targeting of demanding biological targets would require higher three-dimensionality (3D).
Our High-Diversity Fragment Library comprises hundreds of in stock compounds with MW ≤ 300, ClogP ≤ 3.0 and TPSA≤ 60, originating from the exploratory work of SpiroChem on the synthesis of sp3-rich (more 3D-like) scaffolds, conformationally-restricted and strained building blocks. To optimize drug-like properties, covalent modifiers and toxicophores have been excluded, and a large set of fluorinated fragments has been included. Noteworthy, our Fragment Library compiles exclusive sp2/sp3 hybrid scaffolds integrating both spirocyclic or bicycloalkyl moieties connected/fused to a heteroaromatic groups. Such unique motif will allow to address unexplored chemical space and tackle undruggable biological targets.
Synthetic tractability is as important as diversity! What would be the use of a complex fragment that you cannot easily modify or evolve later on? Our motto is “Make the molecules you SHOULD, not just the one you COULD”. At SpiroChem, we do not only provide milligrams of each Fragment! Because we master the synthesis of our complex Fragments, we offer synthetic tractability of all the chemical series that we propose. We can provide you with fast-analoging solutions, additional quantities of each Fragment Hit and support in securing new Intellectual Property domains. We will assist you during the Fragment Evolution phase. And if things go well, we can be your outsourcing partner to explore the chemistry further and help you bring your products to lead series and beyond.
In addition, we can synthesize sub-series and propose bioisosteric replacement to expand your research towards new IP.