SpiroKit 1
pKa-tuned amines
SpiroKit 1 is a smart selection of 66 amines with modulated pKa to help medicinal chemists consider the full potential of the basic centres carefully.
Strong basic centres (pKa > 10) are likely to be fully ionized at a physiological pH of 7.4 and are then unlikely to cross membranes by passive diffusion. Moreover, strong basic molecules are known to lead to hERG toxicity issue, high P-gp efflux and significant binding with α-acid glycoprotein in plasma.
To help you anticipate these issues and make you save time in your research programs, SpiroChem designed the pKa-tuned amines SpiroKit.
A selection of 7 azetidine-like derivatives with modulated pKa.
Catalog ID | Compounds | Amount (each) | Price | |
---|---|---|---|---|
SPK1a | 7 | 100mg | CHF 940 | USD 1.119 |
250mg | CHF 1.880 | USD 2.109 | ||
500mg | CHF 2.960 | USD 3.319 |
A selection of 9 pyrrolidine derivatives with modulated pKa.
Catalog ID | Compounds | Amount (each) | Price | |
---|---|---|---|---|
SPK1b | 9 | 100mg | CHF 670 | USD 749 |
250mg | CHF 1.270 | USD 1.419 | ||
500mg | CHF 1.990 | USD 2.219 |
A selection of 12 piperidine derivatives with modulated pKa.
Catalog ID | Compounds | Amount (each) | Price | |
---|---|---|---|---|
SPK1c | 12 | 100mg | CHF 740 | USD 829 |
250mg | CHF 1.480 | USD 1.659 | ||
500mg | CHF 2.360 | USD 2.639 |
A selection of 6 advanced piperidine derivatives with modulated pKa.
Catalog ID | Compounds | Amount (each) | Price | |
---|---|---|---|---|
SPK1d | 6 | 100mg | CHF 1.020 | USD 1.139 |
250mg | CHF 1.990 | USD 2.229 | ||
500mg | CHF 2.990 | USD 3.339 |
A selection of 8 piperazine derivatives with modulated pKa.
Catalog ID | Compounds | Amount (each) | Price | |
---|---|---|---|---|
SPK1e | 8 | 100mg | CHF 1.150 | USD 1.289 |
250mg | CHF 2.190 | USD 2.449 | ||
500mg | CHF 3.500 | USD 3.909 |
A selection of 4-amino-piperidine derivatives with modulated pKa.
Catalog ID | Compounds | Amount (each) | Price | |
---|---|---|---|---|
SPK1f | 9 | 100mg | CHF 1.990 | USD 2.219 |
250mg | CHF 3.780 | USD 4.229 | ||
500mg | CHF 6.040 | USD 6.749 |
A selection of 3-amino-piperidine derivatives with modulated pKa.
Catalog ID | Compounds | Amount (each) | Price | |
---|---|---|---|---|
SPK1g | 4 | 100mg | CHF 840 | USD 939 |
250mg | CHF 1.600 | USD 1.789 | ||
500mg | CHF 2.560 | USD 2.859 |
A selection of 3-amino-pyrrolidine derivatives with modulated pKa.
Catalog ID | Compounds | Amount (each) | Price | |
---|---|---|---|---|
SPK1h | 5 | 100mg | CHF 940 | USD 1.049 |
250mg | CHF 1.790 | USD 1.999 | ||
500mg | CHF 2.860 | USD 3.199 |
A selection of 6 bicyclic diamino derivatives with modulated pKa.
Catalog ID | Compounds | Amount (each) | Price | |
---|---|---|---|---|
SPK1j | 6 | 100mg | CHF 1.690 | USD 1.889 |
250mg | CHF 3.210 | USD 3.589 | ||
500mg | CHF 5.130 | USD 5.739 |
To place an order please contact Laurence Jung, PhD: laurence.jung@spirochem.com, and indicate the SpiroKits of interest with the required quantities.