The side chain topography of amino acids represents a crucial structural feature in drug design and constraining the side chain dihedral angles limits conformational flexibility. This makes constrained amino acids highly diverse elements for SAR campaigns, integral components of peptidomimetic drugs and invaluable motifs to improve potency, selectivity and ADME properties.
A selection of 11 N-Boc protected constrained α,α-disubstituted amino acids with modulated lipophilic side chain.
Catalog ID | Compounds | Amount (each) | Price | |
---|---|---|---|---|
SPK3a | 11 | 100mg | CHF 1.750 | USD 1.959 |
250mg | CHF 2.500 | USD 2.799 | ||
500mg | CHF 3.270 | USD 3.669 | ||
1000mg | CHF 4.350 | USD 4.879 |
A selection of 8 constrained amino esters with an exit vector on the side chain optimal to create a 3D conformationnally restricted scaffold with 3 functionalizable handles.
Catalog ID | Compounds | Amount (each) | Price | |
---|---|---|---|---|
SPK3b | 8 | 100mg | CHF 1.950 | USD 2.189 |
250mg | CHF 3.310 | USD 3.709 | ||
500mg | CHF 4.920 | USD 5.519 | ||
1000mg | CHF 6.990 | USD 7.839 |
A diversified selection of 13 proline analogs considering bridged rings, fused rings and ring size variation.
Catalog ID | Compounds | Amount (each) | Price | |
---|---|---|---|---|
SPK3c | 13 | 100mg | CHF 1.660 | USD 1.859 |
250mg | CHF 2.820 | USD 3.159 | ||
500mg | CHF 4.230 | USD 4.749 | ||
1000mg | CHF 6.340 | USD 7.109 |
A selection of 10 N-Boc protected constrained β-amino acids
Catalog ID | Compounds | Amount (each) | Price | |
---|---|---|---|---|
SPK3d | 10 | 100mg | CHF 3.440 | USD 3.859 |
250mg | CHF 5.850 | USD 6.559 | ||
500mg | CHF 8.770 | USD 9.839 | ||
1000mg | CHF 13.150 | USD 14.749 |
A selection of 8 N-Boc protected spiro acid derivatives considering length and angle variation between the two handles.
Catalog ID | Compounds | Amount (each) | Price | |
---|---|---|---|---|
SPK3е | 8 | 100mg | CHF 1.920 | USD 2.159 |
250mg | CHF 2.980 | USD 3.339 | ||
500mg | CHF 4.470 | USD 5.009 | ||
1000mg | CHF 6.900 | USD 7.739 |
To receive more information about the SpiroKits, please contact Laurence Jung, PhD: laurence.jung@spirochem.com