Aryl amines are prevalent motifs in high-throughput screening libraries but have proven to be particularly disruptive in late-stage drug development because of their propensity to generate reactive metabolites. Moreover, many sp2-rich lead molecules fail due to their poor pharmacokinetic properties.
Thanks to their similarity in size and shape, conformationally restricted systems and particularly cage like systems are unique classes of sp3 rigid linkers able to mimic benzene moieties. Thay are designed to help you:
A selection of 9 bicyclo[1.1.1]pentan-1-amine derivatives diversifically substituted in position 3 and considered as priviligiated surrogates of substituted anilines.
SPIROKIT 2a is the must-have toolbox to have in stock for all your medchem programs to quickly evaluate the impact of the BCP motif on:
Catalog ID | Compounds | Amount (each) | Price | |
---|---|---|---|---|
SPK2a | 9 | 100mg | CHF 2.150 | USD 2.419 |
250mg | CHF 4.290 | USD 4.829 | ||
500mg | CHF 6.890 | USD 7.749 | ||
1000mg | CHF 10.750 | USD 12.099 |
SPIROKIT 2b is a selection of 7 di-amino rigid
sp3 systems and the must-have toolbox to:
Catalog ID | Compounds | Amount (each) | Price | |
---|---|---|---|---|
SPK2b | 7 | 100mg | CHF 1.860 | USD 2.099 |
250mg | CHF 3.870 | USD 4.359 | ||
500mg | CHF 6.200 | USD 6.989 | ||
1000mg | CHF 8.990 | USD 9.999 |
A selection of 8 bifunctionalized rigid sp3 systems with an amino group and an ester as exit vectors.
SPIROKIT 2c is the must-have toolbox to:
Catalog ID | Compounds | Amount (each) | Price | |
---|---|---|---|---|
SPK2c | 8 | 100mg | CHF 1.940 | USD 2.179 |
250mg | CHF 3.890 | USD 4.379 | ||
500mg | CHF 6.230 | USD 7.009 | ||
1000mg | CHF 10.890 | USD 12.249 |
A selection of 9 bifunctionalized rigid sp3 systems with an amino group and a hydroxy group as exit vectors.
SPIROKIT 2c is the must-have toolbox to:
Catalog ID | Compounds | Amount (each) | Price | |
---|---|---|---|---|
SPK2d | 9 | 100mg | CHF 1.180 | USD 1.329 |
250mg | CHF 2.400 | USD 2.699 | ||
500mg | CHF 4.100 | USD 4.619 | ||
1000mg | CHF 5.860 | USD 6.599 |
To receive more information about the SpiroKits, please contact Laurence Jung, PhD: laurence.jung@spirochem.com