In 2021-2022, SpiroChem has performed 15 successful Route Scouting projects for biotechs, big pharma and CMO/CDMOs.
Our success is based on:
Our deep knowledge and expertise that enables us to analyze critically existing data and generate many hypothetical alternatives ranging from complete de novo synthesis to smart tuning/orchestrating of existing sequences.
Our rapid-triage that allows to test, challenge and rank all short-listed ideas. Very quickly, we are able to select one preferred route and prepare first scale-up.
Our outstanding ability to assess the selected route by screening alternative reaction conditions considering impurity profiles and suggesting in-process controls. Scalability is probed (factor 3-10) while purification strategies and telescoping opportunities are implemented to pave the way for process optimization.
We provide a tailored team of experts to fit your needs and can support you in the preparation of:
Conformationally restricted scaffolds
sp2-sp3 hybrid molecules (organocatalysis, photochemistry)
Chiral molecules (enantioselective synthesis)
Macrocycles
Biomolecules (glycosyl derivatives, fatty acids, small peptides, nucleosides/tides)
Probes and/or linker for chemical biology
Natural products (total synthesis)
High-potent molecules
We would be happy to evaluate your project, please contact us at contact@spirochem.com.
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