We design and implement de novo synthetic routes and strategies to molecules of interest.
Our chemists have a track record of success for the delivery of novel and efficient synthetic routes to molecules of interest in a time-efficient way.
By a combination of extraordinary deep knowledge of classical synthetic chemistry, unrivalled command of modern synthetic methodologies and a flair for efficient and smart solutions, we rapidly evaluate the hurdles, bottlenecks and opportunities of a known synthetic route and provide many new alternatives to evaluate. We offer:
Although we do not perform pure process optimizaiton, we can liaise with partner companies in the field who can then refine and prepare target molecules on scale for pre-clinical/clinical/commercial phase.
Upon implementation in the laboratory, the most promising approaches are evaluated, compared and further elaborated to deliver a new synthetic route meeting the requirements of the project in terms of scalability, cost or intellectual property.
A demo batch is usually peformed on 100g scale to test the robustness of the novel synthesis and provide sufficient quantities of test material to support further evaluation and R&D.
A technology transfer package is prepared and SpiroChem supports the transition to a CMO of choice.
Our chemists are recruited and trained to think outside of the box. Their mission is to solve problems and make your project succeed.
Problem: Advanced candidate containing a bicyclo [1.1.1]pentane motif; Tried for many months to scale-up synthesis of a bicyclo [1.1.1]pentane intermediate (in China) and failed; Timing became critical for customer
Note: SpiroChem is world leader in the chemistry of bicyclo[1.1.1]pentanes
SpiroChem assigned two chemists on FTE-based contract, with technology-access fee to SpiroChem know-how and success fees
Within 4 months:
SpiroChem successfully designed a scalable synthetic route for late-stage introduction of BCP ring
Manufactured 100g+ of advanced material (demo batch) to support downstream process optimization
Happy client is now in the clinic and regularly comes back to SpiroChem for more services and solutions
Market Savings estimated by customer to several millions USD
Who: Clinical-stage biotech (entering phase III)
Problem: API contains a complex spirocycle, current route to spirocyclic motif not scalable (7 steps: cryogenic conditions, toxic reagents, purification problems, flammable reagents, 10-15% overall yield)
SpiroChem assigned one chemist on FTE-based contract: within 6 months:
Route-scouting and identification of 5-transformation sequence
Reduction to a 2-pot process by telescoping steps
55% overall yield on 50g scale
Only one crystallization (intermediate) and one extraction (last step)
Investigation of reaction mechanism and identification of by-products
Development of IPCs
Fine tune conditions: overall yield: 70-80%, demo batch on 500g+
Successful technology transfer to CMO and scale-up to 100kg+
It is with great joy that I am recommending SpiroChem based on the excellent job they did for us; Their high flexibility and reactivity to our fast changing requests was outstanding. Furthermore, SpiroChem's excellent synthetic expertise enabled access to a key API, which we tested and proved to be the basis for the IP of a complete class of substances. Last but not least, I want to emphasize the outstanding communication and the fast delivery of the very detailed and precise final report with all the analytical documentation included.