SpiroChem AG:
Rosental area, WRO-1047-3
Mattenstrasse 24
4058 Basel, Switzerland
Tel: + 41 61 685 95 00
E-mail: contact@spirochem.com
Swiss Fine Chemicals
By a combination of extraordinary deep knowledge of classical synthetic chemistry, unrivalled command of modern synthetic methodologies and a flair for efficient and smart solutions, we rapidly evaluate the hurdles, bottlenecks and opportunities of a known synthetic route and provide many new alternatives to evaluate. We offer:
Although we do not perform pure process optimizaiton, we can liaise with partner companies in the field who can then refine and prepare target molecules on scale for pre-clinical/clinical/commercial phase.
Our chemists are recruited and trained to think outside of the box. Their mission is to solve problems and make your project succeed.
Who: Biotech
Where: Confidential
Problem: Advanced candidate containing a bicyclo [1.1.1]pentane motif; Tried for many months to scale-up synthesis of a bicyclo [1.1.1]pentane intermediate (in China) and failed; Timing became critical for customer
Note: SpiroChem is world leader in the chemistry of bicyclo[1.1.1]pentanes
SpiroChem assigned two chemists on FTE-based contract, with technology-access fee to SpiroChem know-how and success fees
Within 4 months:
SpiroChem successfully designed a scalable synthetic route for late-stage introduction of BCP ring
Manufactured 100g+ of advanced material (demo batch) to support downstream process optimization
Happy client is now in the clinic and regularly comes back to SpiroChem for more services and solutions
Market Savings estimated by customer to several millions USD
Who: Clinical-stage biotech (entering phase III)
Where: USA
Problem: API contains a complex spirocycle, current route to spirocyclic motif not scalable (7 steps: cryogenic conditions, toxic reagents, purification problems, flammable reagents, 10-15% overall yield)
SpiroChem assigned one chemist on FTE-based contract: within 6 months:
Route-scouting and identification of 5-transformation sequence
Reduction to a 2-pot process by telescoping steps
55% overall yield on 50g scale
Only one crystallization (intermediate) and one extraction (last step)
Investigation of reaction mechanism and identification of by-products
Development of IPCs
Fine tune conditions: overall yield: 70-80%, demo batch on 500g+
Patent filed
Successful technology transfer to CMO and scale-up to 100kg+