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Molecule of the Week

Take a closer look at our SPC-w136 Small fluoroalkyl chains for ADME modulation

Available at SpiroChem

Small fluoroalkyl chains for ADME modulation

It has been demonstrated that the fluorination pattern of Small alkyl chains affects lipophilicity, solubility and metabolic stability.ref

Effect on the shape of the chain (Gauche effect) was also observed, offering an opportunity for rational design of the conformational restriction of such chains.

  • We offer a range of small fluoroalkyl amines, alcohols and acids for focused SAR to replace/optimize Small alkyl chains.
  • Enantiopure analogs available on demand.
  • Service: late-stage introduction of fluoroalkyl chains (not necessarily connected to amine/alcohol/acid) on your scaffolds of interest on demand.
  • Other alkyl chain length and pattern available on demand.


Ref: Carreira, Müller and coworkers - J. Fluorine Chem. 2013, 152, 119
J. Med. Chem. 2015, 58, 9041


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