It has been demonstrated that the fluorination pattern of Small alkyl chains affects lipophilicity, solubility and metabolic stability.^ref

Effect on the shape of the chain (Gauche effect) was also observed, offering an opportunity for rational design of the conformational restriction of such chains.

• We offer a range of small fluoroalkyl amines, alcohols and acids for focused SAR to replace/optimize Small alkyl chains.
• Enantiopure analogs available on demand.
• Service: late-stage introduction of fluoroalkyl chains (not necessarily connected to amine/alcohol/acid) on your scaffolds of interest on demand.
• Other alkyl chain length and pattern available on demand.

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Ref: Carreira, Müller and coworkers - J. Fluorine Chem. 2013, 152, 119
J. Med. Chem. 2015, 58, 9041