Take a closer look at our SPC-w136 Small fluoroalkyl chains for ADME modulation
It has been demonstrated that the fluorination pattern of Small alkyl chains affects lipophilicity, solubility and metabolic stability.ref
Effect on the shape of the chain (Gauche effect) was also observed, offering an opportunity for rational design of the conformational restriction of such chains.
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Ref: Carreira, Müller and coworkers - J. Fluorine Chem. 2013, 152, 119
J. Med. Chem. 2015, 58, 9041