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Molecule of the Week

Rigid Piperazine Isosteres. Take a closer look at SPC-w129

Available at SpiroChem

Rigid Piperazine Isosteres

Piperazine is one of the most widely used heterocycles in medicinal chemistry.

  • Rigid versions allow for modulation of properties (solubility, metabolic stability, …)
  • Rigidification through spiro/bicyclo/bridge: many other azaheterocycles in stock
  • Synthesis of analogues with additional groups and exit vectors on demand

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