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Rosental area, WRO-1047-3
Mattenstrasse 24
4058 Basel, Switzerland


Tel: + 41 61 685 95 00
E-mail: contact@spirochem.com


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SpiroChem Fragment Library: Your key to successful drug discovery.
Mar 07 2019

New Products & Concept

SpiroChem Fragment Library: Your key to successful drug discovery.


Properly designed libraries, with more complex fragments (typically 3D small molecules) can reduce the rate of false positives and provide excellent starting points for drug discovery programs. The rationale is that scaffolds with a three-dimensional character have better chances of binding to biological targets. This comes from the simple observation that all natural products, i.e. biologically relevant proteins and their ligands, are chiral and three-dimensional.

Explore new chemical space with our premium sp3-enriched fragment libraries.

SpiroChem designs readily-available sp3-enriched fragment libraries to support Life Sciences companies in exploring new chemical spaces and generating IP-protected starting points for drug design. These libraries are unique and give access to an immense, uncharted chemical space.

Our database already includes over 1000 exclusive compounds specially designed for Fragment-Based drug discovery and we are constantly synthesizing new ones.

Fragment evolution programs:

Scale up of fragment, introduction of exit vectors, points of derivatization documented and communicated

Fragment diversity:

>250 original Murko scaffolds available

Novel design:

>50 original fragments synthesized monthly sp3-enriched

SpiroChem’s FBL libraries (yellow and red) vs FBL libraries of other providers
Fragment Library

Tired of the same commercial libraries with flat scaffolds?

Explore new chemical space with our premium sp3-enriched fragment libraries.

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