SpiroChem is proud to present its autumn collection of new products.
Two series of novel thia-azaspiro[3.4]octanes were added to our catalog. These new SpiroBlocks were developed by the Carreira group at ETH-Zürich.(1) The authors « reasoned that the inclusion of a heteroatom, such as sulfur, particularly in its oxidized state, at different positions of the spirocycle would serve to generate uncharted spiro-[3.4]octanes that intuitively resemble “drug-like” fragments ».
These products will open new avenues for medicinal chemists who want to explore unchartered chemical space. The two exit vectors offer a diversity of 3-dimentional shapes and will surely find their place in every medicinal chemist’s tool box.
Contact us for information and prices.(2)
Your SpiroChem Team
(1) Li, D. B.; Rogers-Evans, M.; Carreira, E. M. Org. Lett. 2011, ASAP.
(2) Contact us