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Expertise of the month: A selection of 54 constrained amino alcohols
Apr 29 2022

Expertise of the month

Expertise of the month: A selection of 54 constrained amino alcohols


The introduction of the very hydrophilic hydroxyl group can cause some metabolism-related troubles which can be circumvented by constrained structures and hindered groups.

To help medicinal chemists save time in their research programs, SpiroChem has designed SpiroKit 6 compiling 54 constrained amino alcohol derivatives.

Subsets 6c, 6d and 6e focuses on amino alcohols with OH shielding to prevent conjugation reactions:

Fused, bridged and spiro derivatives give access to 3D structures with improved properties:

We will be happy to support your projects.
For more information, please contact Laurence Jung at laurence.jung@spirochem.com.

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