SpiroChem AG:
Rosental area, WRO-1047-3
Mattenstrasse 22
4058 Basel, Switzerland

Tel: + 41 61 685 95 00
E-mail: contact@spirochem.com


Swiss Fine Chemicals

Search by SPC, Chemical Name, CAS or keyword

Expertise of the month: PROTACS and Molecular Glues
May 31 2022

Expertise of the month

Expertise of the month: PROTACS and Molecular Glues

Targeted Protein Degradation (TPD) is a hot topic in drug discovery today. PROteolysis Targeting Chimeras (PROTACs) and molecular glues provide an approach for the targeted degradation of a protein of interest (POI) with a small molecule.

SpiroChem discovery team has identified leads across several projects.

On PROTACs and molecular glues projects, SpiroChem chemists bring support for:

  • Developing efficient synthesis of E3 ligase recruiters such as Thalidomide, Lenalidomide, VHL, ….
  • Introducing diversified handles on E3 ligase recruiters
  • Connecting various warheads

For PROTACs projects, SpiroChem chemists use their expertise for escaping from usual PEG linkers.

PEG Linker
  • High risk of hydrophobic collapse
  • Low solubility
  • Limited IP space
SpiroChem linkers
SpiroChem designs novel linkers containing 3D constrained modules to:
  • Minimize hydrophobic collapse and reduce the risk of aggregation of the complex
  • Improve PhysChem properties of the complex
  • Generate novel IP space

We will be happy to support your projects.
For more information, please contact Laurence Jung at laurence.jung@spirochem.com.


Don’t miss out on what is important.

Let us inspire you. Subscribe now to keep updated on new concepts, products, solutions & more.