Expertise of the month: Libraries of sp³-rich Covalent Fragments and Fragments

3D fragments are increasingly being considered as complementary to their 2D counterparts and as crucial components to improve pharmacophore coverage and solubility, leading to better starting points for lead generation.

At SpiroChem, we’re using our knowledge and know-how to design novel sp³-rich fragments with high 3D diversity shape.

410 COVALENT FRAGMENTS

Acrylamide derivatives

Propiolamide derivatives

α-Halomethyl amide derivatives

Fluorosulfate derivatives

• In stock
• QC certified by HPLC & NMR
• Available as powder from 1 mg

480 sp³-rich FRAGMENTS

sp³ fragments

sp³-sp³ fragments

sp²-sp³ fragments

• In stock
• QC certified by HPLC & NMR
• Available plated in DMSO
• Soluble at 100mM in DMSO
• Standard format : 100µL at 50mM in DMSO
• More fragments available as powder

We will be happy to support your projects.

For more information, please contact Laurence Jung at laurence.jung@spirochem.com.