3D fragments are increasingly being considered as complementary to their 2D counterparts and as crucial components to improve pharmacophore coverage and solubility, leading to better starting points for lead generation.
At SpiroChem, we’ve used our in-house knowledge and know-how to design novel sp3-rich fragments with high 3D diversity shape. The fragment collection can be categorized in 3 subfamilies:
All fragments are soluble at 100mM in DMSO and are QC certified by NMR.
Customized volumes and concentrations available upon request.
Customer’s most recent screening results:
TA: neurodegenerative diseases.
In vivo C. elegans development assay: Confirmation of hits in vivo.
We will be happy to support your projects.
For more information, please contact Laurence Jung at email@example.com.