"Dear Colleagues, we invite you to check out a recent article in ChemMedChem (DOI: 10.1002/cmdc.201700082) by scientists at Novartis (Basel, Switzerland) on the impact of 2D->3D isosteric switches on non-specific binding and solubility. SpiroChem is proud to have contributed to this project with Novartis. This shows the yet underestimated potential of bicyclo[1.1.1]pentanes and cubanes in drug discovery."
SpiroChem is the world-leading supplier of bicyclo[1.1.1]pentanes and cubanes and a specialist on bio-isosteric strategies with the largest portfolio of solutions for ADME optimization, scaffold-hopping and chemical space exploration.