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Improving Nonspecific Binding and Solubility: BicycloalkylGroups and Cubanes as para-Phenyl Bioisosteres | ChemMedChem Article - SpiroChem.
Apr 19 2017

Press Release

Improving Nonspecific Binding and Solubility: BicycloalkylGroups and Cubanes as para-Phenyl Bioisosteres | ChemMedChem Article - SpiroChem.


"Dear Colleagues, we invite you to check out a recent article in ChemMedChem (DOI: 10.1002/cmdc.201700082) by scientists at Novartis (Basel, Switzerland) on the impact of 2D->3D isosteric switches on non-specific binding and solubility. SpiroChem is proud to have contributed to this project with Novartis. This shows the yet underestimated potential of bicyclo[1.1.1]pentanes and cubanes in drug discovery."

About SpiroChem:

SpiroChem is the world-leading supplier of bicyclo[1.1.1]pentanes and cubanes and a specialist on bio-isosteric strategies with the largest portfolio of solutions for ADME optimization, scaffold-hopping and chemical space exploration.

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