This is a story about how SpiroChem rescued a failed tech transfer from near disaster and turned it into a success. A story about a promising molecule’s path to phase 1 clinical trials, jeopardized by an unoptimized synthetic route.
When a Swiss biotech contacted SpiroChem, they were at a critical point. Their tech transfer to their CDMO of choice failed during the 5th step (out of 6), leaving them with kilograms of unusable crude reaction mixture.
In just three months, SpiroChem redesigned the process into a 2-step synthesis, introducing stereocenters last via C-H activation. Then successfully delivered 200g of compound for toxicology studies, followed by a seamless tech transfer to a Swiss CDMO.
Moral of the story? Always entrust your chemistry to the best partner!
Our Route Scouting experts are ready to help you optimize your synthetic routes and streamline your projects towards success.
