Camp 4: Unlocking access to novel medicines

SpiroChem is committed to foster your Medicinal Chemistry programs either by supporting you from hit identification to pre-clinical candidate selection or by being involved in very specific phase(s) of your project.

We are involved in programs across different therapeutic areas and target families from small molecules to bifunctional molecules and macrocycles.

With two dedicated labs, we can also handle high-potent molecules and support ADC program by designing and synthesizing novel linker-payload complexes.

Thanks to a team of 100+ highly skilled scientists (65% PhDs, 35% MScs), strong management and the use of Enabling Technologies, SpiroChem tackles, challenges and brings creativity, innovation and productivity to your projects.

SpiroChem performs fast iterative optimization cycles combining:

CompChem Expertise

Pharmacophore-based screenings
High-throughput docking
Fragment-based approach
Scaffold-hopping
3D Drug Design
Fragment-based approach
Proprietary virtual Libraries
Bio Switcher algorithm

Medicinal Chemistry Expertise

SAR & Early ADME data analysis
Properties optimization/fine-tuning
Bioisosteric replacement strategies
Novel chemical space exploration
IP evaluation / securing
Patent exempflication

Unrivalled Synthetic Skills

In-house Enabling Technologies: Photochemistry/Photoredox, Flow chemistry, Electrochemistry, Biocatalysis
Late-stage functionalization
New exit vector opening
Focused library preparation
Proprietary chemistry