Search by keyword.
Macrocycles offer a diverse chemical space that bridges the gap between small molecules and larger biologics, often exhibiting high potency, selectivity, and improved pharmacokinetic properties. The constrained and often rigid structures of macrocycles provide increased stability and binding affinity to their targets, enabling them to interact with challenging protein-protein interfaces or unconventional binding sites that traditional small molecules might struggle to access. Moreover, their larger size allows for more specific interactions with biological targets, reducing off-target effects.
We specialize in the design, synthesis, and optimization of macrocycles, using advanced synthetic methodologies and deep scientific expertise to develop molecules with optimized pharmacokinetic and pharmacodynamic properties.
Regardless the project entry scenario, SpiroChem offers comprehensive expertise in the design and synthesis of novel macrocycles with small-molecule–like properties, supporting innovative drug discovery programs.
Screening technologies enable the rapid identification of novel hits by exploring vast and diverse chemical spaces. SpiroChem supports this process from screening to lead identification by combining the power of parallel chemistry on the Hercules+™ platform for hit validation and hit-to-lead (H2L) with expert chemistry for lead optimization.
By leveraging X-ray structures, pharmacophoric features, and known ligands from the literature, we identify key binding interactions and strategically connect them into conformationally optimized macrocyclic scaffolds. This approach locks in bioactive geometries while enhancing potency, selectivity, and stability—transforming structural data into powerful molecular design
Despite the proven success of macrocycles in modulating challenging drug targets across multiple therapeutic areas, their full potential in drug discovery and development remains largely untapped, primarily due to synthetic challenges.
The robustness of our Hercules+™ platform combined with our excellence in chemistry enable the synthesis of tailored macrocycles, pushing the boundaries of what can be achieved in drug discovery.
