We are committed to generating and selecting high-quality lead compounds to help you reach clinics faster and safer
We offer high-skilled scientists coming from industry and academia to create synergic teams with unleashed creativity and active management from senior scientists with years of expertise in your field.
That triggered a particular mindset within the company, where we think of every problem as a challenge in which we must succeed. And we have been good at it!
We provide full medchem programs from hit validation to identification of the preclinical candidate or support for a specific phase of your project such as:
Thanks to continuous in-house research to explore new chemical space and troubleshoot synthetic issues, we have cutting-edge expertise in design, bio-isosteric replacement and scaffold hopping. At SpiroChem, we prepare the molecule we should not the one we could.
Equipped with peformant devices such as TLC/MS, Bench Top NMR, high-throughput purification machines, we optimize and save time to make your project advance faster.
Through +14 000 references in our catalog and dedicated SpiroKits, we have a direct access to smart building blocks and turnkey solutions.
Typical FTE-based research contracts
Specific Chemistry Skills
Problem: Design, synthesis and optimization of novel bicyclo[x.y.z]alkane derivatives
SpiroChem assigned one chemist of FTE-based contact for 6 months:
4 series developed : 20 final molecules delivered (5 to 15 steps)
New methodology developed for the synthesis of bicyclo[x.y.z]-pyrazole derivatives by modification of key functionalities
Successful introduction of 10 new bicyclo[x.y.z]alkane derivatives for use as non-classical bioisosteres
Validation of bioisosteric switch concept
Generation of novel chemical space
3D design confirmed by X-Ray cryatallography
Subnanomolar activity and excellent ADME profile achieved
SpiroChem has played an instrumental part in Cellestia’s drug discovery and development program, proving to be a reliable partner in delivering quality results in a timely manner. Within the framework of this collaboration, the team has spared no effort in meticulously executing the plan and actively participating in project meetings to contribute to the success of our medicinal chemistry efforts. SpiroChem’s innovative and effective work helped us save CHF 0,5 million on the drug development program. I thoroughly enjoyed interacting with SpiroChem’s team and CEO Dr. Thomas Fessard who always made himself personally available to discuss the progress of our projects. Without any reservations, I would highly recommend SpiroChem to anyone looking for customized, innovative chemistry from a highly invested, strikingly professional team.
SpiroChem services have been invaluable with lead optimization, starting with medicinal chemistry advice, following with compound synthesis, and finally reporting. We now have a more comprehensive understanding of the structure-activity relationship and a more solid foundation for our IP. The SpiroChem team are very efficient and deliver excellent quality on time, providing good value for money.