We develop medchem-ready chemical series by opening new exit vectors on hit- or lead-like scaffolds.
It accelerates discovery efforts by providing efficiency gains during SAR and by shortening each optimization cycle.
Whether during hit evolution, hit-to-lead or lead optimization phase, the ability to rapidly and efficiently explore each position on the structure of interest allows for more rapid optimization. We offer :
By removing the uncertainty of «will my chemists be able to make this analog» , we unleash the creativity of the computational chemists, designer and project managers. They can now focus on making and testing molecules that are meaningful to advance the project and validate hypotheses, rather than limiting only to molecules that they could make.
SpiroChem chemists are used to serve as the A-team of chemistry for larger groups of chemists, collaborating directly with our client’s internal teams or their third-party CROs.
Who: Big Pharma
Goal: Synthesis of diazaspiro derivatives with novel substitutions and exit vectors (5g scale)
SpiroChem assigned one chemist on FTE-based contract for 6 weeks
Development of a 9 step synthesis
Successful application of flow chemistry (H-cube technology)
Validation of the synthesis at 5g scale
Sustainable route for the preparation of additional diversified analogs
Who: Animal Health Care Company
Goal: Design and synthesis of novel 3D spiro scaffolds
SpiroChem assigned one chemist on FTE-based contract for 4 months
Development of a 8 step synthesis
Introduction of diversified protecting groups for highest versatility
Validation of the synthesis at 10g scale
Outcome : US patent application
SpiroChem is a truly outstanding partner for the synthesis of customized building blocks, combining high technical expertise, creativity and a strong commitment with a very collaborative approach and a focus on delivery. Excellent communication, innovative ideas at the start of the project and proactive problem-solving by the SpiroChem team contribute to the success of projects. I have no hesitation in recommending SpiroChem.
Our collaboration with SpiroChem has enhanced our ability to investigate novel chemical space. The SpiroChem team and our team have built an outstanding partnership, working closely to resolve tough synthetic issues and quickly explore areas, which - without their expertise - would have been challenging. Their emphasis on communication, rapid delivery with uncompromised quality and troubleshooting solutions makes SpiroChem a highly recommended partner.
SpiroChem’s expertise in synthetic chemistry, combined with their sense of urgency, makes them the ideal partner for exploring new chemical space. Our critical collaboration on bicycloalkyl bioisosteres was published on ChemMedChem 2017 12 590. I have to highlight the ease of communication and the proactive role of SpiroChem, which we regularly experienced in our interactions. They are brilliant partners to work with, both for standard synthesis or more demanding customized building blocks and I would recommend their services to any company seeking pragmatic, cutting-edge solutions.
In SpiroChem we found a partner with unparalleled industry knowledge, willing to support start-ups like AgroSustain with cost-effective solutions. With a broad expertise and efficiency, the SpiroTeam took the time to understand the complexities of our business and never failed to answer our requests. Consistently, they delivered against our requirements – namely by synthesizing or upscaling tailor-made products. I recommend SpiroChem for their formidable support and services without hesitation.