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Cubanes

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Grid  List 

Items 1 to 15 of 67 total

Page:
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  4. 4
  5. 5
per page
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Cubanes are useful chemical tools for bioisosteric replacement of aromatic and lipophilic groups. Our current range of cubanes are rigid scaffolds with one or two exit vectors positioned in a linear manner (1,4 substitution), thereby mimicking the para substitution pattern on arenes or tert-butyl/lipophilic moieties.

Why Cubanes?

Cubanes have recently been highlighted in the scientific literature as useful chemical tools for bioisosteric replacement of aromatic groups. Cubanes are rigid scaffolds. Our range of cubanes have one or two exit vectors positioned in a linear manner (1,4-substitution), thereby mimicking the para substitution pattern on arenes.

Cubanes are three-dimensional fragments and were shown to display equivalent or improved physico-chemical and pharmaco-kinetic properties compared to the arene groups they are replacing. Therefore, when the arene group is serving as a spacer/scaffold and is not involved in Pi interactions with the biological target, switching to the corresponding cubane is strongly recommended.

We also postulate that mono-substituted cubanes can also serve as lipophilic group replacement and can be considered as bioisosteres of tert-butyl groups. Cubanes are now standard components of our LipoSwitch kits and services.

Why SpiroChem?

SpiroChem is a world-leading player in the design, synthesis and manufacturing of Cubanes. Most of the Cubanes can be offered on multi-gram scale and up to kilogram scale, in a short lead time and are affordable to support your drug discovery programs and beyond.

SpiroChem can provide these advanced building blocks containing Cubanes from our comprehensive catalog, but also design synthetic routes to new series that are fit for your applications and that will facilitate their introduction in your molecules of interest, thereby reducing the amount of synthetic work that needs to be done and allowing you to focus on high-value- added transformations. So do not hesitate asking us for derivatives of our catalog products!

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