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Pyridines


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Substituted pyridines are moderately basic heterocyclic organic compounds used as privileged scaffolds in medicinal chemistry. Pyridines can be related to the well-established and fundamental aromatic molecule, benzene. On the contrary to aryl group, substituted pyridines are less prone to oxidation and can be serve as hydrogen bond acceptor for enhancing solvation or binding to biological targets.

Why Pyridines?

The pyridine heterocycle remains central in the development of human medicines. More than 100 drugs that are currently active on the market, including the blockbuster drugs Nexium®, Claritin®, and the recently approved cancer therapeutic Xalkori®, contain this privileged motif.

Pyridine derivatives possess moderate to excellent activities against a large number of biological targets, such as enzymes, proteins and DNA. Modulation of the substituents on the pyridine core provides selectivity towards the biological targets and the derivatives are very much used as antiviral, antimicrobial, anticancer, antidiabetic & antithrombic agents etc.

Why SpiroChem?

Being aware of the immense value of the pyridines, SpiroChem has developed a library of >1000’s functionalized derivatives of this privileged heterocycle with substitutions such as difluoromethyl, trifluoromethyl, oxetanyl groups or perfluoroalkyl chains and more, which allows for fine tuning of properties. Additionally, pyridines derivatives offered by SpiroChem contain substitution patterns, like boronic acid, amine or carboxylic acid, for a rapid and efficient coupling of these building blocks into larger molecules.

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