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Mattenstrasse 24
4058 Basel, Switzerland


Tel: + 41 61 685 95 00
E-mail: contact@spirochem.com


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SpiroKit 1

pKa-Tuned Amines

Basic centres are highly recurrent in drug discovery but to exploit the full potential of these motifs, their pKa parameter should be considered carefully.

SpiroKit 1: pKa-Tuned Amines

Why SpiroKit 1?

Strong basic centres (pKa > 10) are likely to be fully ionized at a physiological pH of 7.4 and are then unlikely to cross membranes by passive diffusion. Moreover, strong basic molecules are known to lead to hERG toxicity issue, high P-gp efflux and significant binding with α-acid glycoprotein in plasma.

To help you anticipate these issues and make you save time in your research programs, SpiroChem designed the pKa-tuned Amines SpiroKit.

SpiroKit 1: pKa-Tuned Amines

Offered subsets

SPIROKIT 1a: Azetidine-like Derivatives

A selection of 7 azetidine-like derivatives with modulated pKa.

Catalog ID Compounds Amount (each) Price
SPK1a 7 100mg CHF 940 USD 999

A selection of 9 pyrrolidine derivatives with modulated pKa.

Catalog ID Compounds Amount (each) Price
SPK1b 9 100mg CHF 670 USD 719

A selection of 12 piperidine derivatives with modulated pKa.

Catalog ID Compounds Amount (each) Price
SPK1c 12 100mg CHF 740 USD 799

A selection of 6 advanced piperidine derivatives with modulated pKa.

Catalog ID Compounds Amount (each) Price
SPK1d 6 100mg CHF 1.020 USD 1.099

A selection of 8 piperazine derivatives with modulated pKa.

Catalog ID Compounds Amount (each) Price
SPK1e 8 100mg CHF 1.150 USD 1.249

A selection of 4-amino-piperidine derivatives with modulated pKa.

Catalog ID Compounds Amount (each) Price
SPK1f 9 100mg CHF 1.990 USD 2.199

A selection of 3-amino-piperidine derivatives with modulated pKa.

Catalog ID Compounds Amount (each) Price
SPK1g 4 100mg CHF 840 USD 919

A selection of 3-amino-pyrrolidine derivatives with modulated pKa.

Catalog ID Compounds Amount (each) Price
SPK1h 5 100mg CHF 940 USD 999

A selection of 6 bicyclic diamino derivatives with modulated pKa.

Catalog ID Compounds Amount (each) Price
SPK1j 6 100mg CHF 1.690 USD 1.859
SpiroKit 1: pKa-Tuned Amines

Request an Order

To place an order please contact Laurence Jung, PhD: laurence.jung@spirochem.com, and indicate the SpiroKits of interest with the required quantities.

SpiroKits

Coming soon

New SpiroKits are coming soon. Fill in the contact form to be informed as soon as they are released.

SpiroKit 2

α,α Disubstituted Amino Acids

SpiroKit 3

Sp2 to Sp3 Switch Systems

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