Amaryllidaceae alkaloids:
(+)-pancratistatin, (+)-lycoricidine, (+)-narciclasine and novel synthetic analogs

Based on the isocarbosyril core.

Cytotoxic activity:

• In vitro RNA antiviral activity
• In vivo murine Japanese encephalitis
• In vitro anti-microsporidium

Natural products available on gram scale and beyond
Large range of analogs can be made on demand
Tractable chemical space for Analoging and downstream SAR