We are committed to generating and selecting high-quality lead compounds to help you reach clinics faster and safer
We offer high-skilled scientists coming from industry and academia to create synergic teams with unleashed creativity and active management from senior scientists with years of expertise in your field.
Our science
How we think.
That triggered a particular mindset within the company, where we think of every problem as a challenge in which we must succeed. And we have been good at it!
It’s all about passion
We assist you all the way to make your projects successful
We provide full medchem programs from hit validation to identification of the preclinical candidate or support for a specific phase of your project such as:
Hit Validation
Lead Optimization
Properties Optimization
IP Evaluation
Hit/Fragment Expansion
SAR Elucidation
Back-up programs
Patent Filing
Hit-to-Lead
Bioisosteric replacement strategies
Access our knowledge
Synthetic chemistry is never a limitation
Thanks to continuous in-house research to explore new chemical space and troubleshoot synthetic issues, we have cutting-edge expertise in design, bio-isosteric replacement and scaffold hopping. At SpiroChem, we prepare the molecule we should not the one we could.
Time is precious
Your success is our priority
Equipped with peformant devices such as TLC/MS, Bench Top NMR, high-throughput purification machines, we optimize and save time to make your project advance faster.
Through +14 000 references in our catalog and dedicated SpiroKits, we have a direct access to smart building blocks and turnkey solutions.
Crafting the world
One thing in common: Passion for chemistry
Typical FTE-based research contracts
1-6 chemists (at least 50% PhD)
Duration : 3-12 months
Strong management (PhD involved in the lab)
Cutting-edge Technologies
Photochemistry
Flow chemistry
Electrochemistry
Parallel synthesis
Microwave-assisted synthesis
Specific Chemistry Skills
Spiro and bicycloalkane derivatives
Sp3 and sp2-sp3 hybrid scaffolds
Natural products
Nucleosides/Nucleotides
Macrocycles
Peptidomimetics
Polysaccharides
FTE (Full-Time Equivalent)
Success Story / MedChem
Who: Biotech
Where: Asia
Problem: Design, synthesis and optimization of novel bicyclo[x.y.z]alkane derivatives
SpiroChem assigned one chemist of FTE-based contact for 6 months:
4 series developed : 20 final molecules delivered (5 to 15 steps)
New methodology developed for the synthesis of bicyclo[x.y.z]-pyrazole derivatives by modification of key functionalities
Successful introduction of 10 new bicyclo[x.y.z]alkane derivatives for use as non-classical bioisosteres
Validation of bioisosteric switch concept
Generation of novel chemical space
3D design confirmed by X-Ray cryatallography
Subnanomolar activity and excellent ADME profile achieved
Testimonials
Dr. Rajwinder Lehal, chief scientific officer, Cellestia Biotech AG.
SpiroChem has played an instrumental part in Cellestia’s drug discovery and development program, proving to be a reliable partner in delivering quality results in a timely manner. Within the framework of this collaboration, the team has spared no effort in meticulously executing the plan and actively participating in project meetings to contribute to the success of our medicinal chemistry efforts. SpiroChem’s innovative and effective work helped us save CHF 0,5 million on the drug development program. I thoroughly enjoyed interacting with SpiroChem’s team and CEO Dr. Thomas Fessard who always made himself personally available to discuss the progress of our projects. Without any reservations, I would highly recommend SpiroChem to anyone looking for customized, innovative chemistry from a highly invested, strikingly professional team.
Testimonials
Pablo German, Chief Technical Officer – Pheromite
SpiroChem services have been invaluable with lead optimization, starting with medicinal chemistry advice, following with compound synthesis, and finally reporting. We now have a more comprehensive understanding of the structure-activity relationship and a more solid foundation for our IP. The SpiroChem team are very efficient and deliver excellent quality on time, providing good value for money.
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